Role of Leishmania (Leishmania) amazonensis amastigote glycosphingolipids in macrophage infectivity
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چکیده
منابع مشابه
Role of Leishmania (Leishmania) amazonensis amastigote glycosphingolipids in macrophage infectivity.
The role of glycosphingolipids (GSLs) present in amastigote forms of Leishmania (Leishmania) amazonensis during infection of macrophages was analyzed, with particular emphasis on GSLs presenting the terminal Galpss1-3Galpa disaccharide. Macrophage invasion by L. (L.) amazonensis amastigotes was reduced by 37% when the disaccharide Galpss1-3Galp (1 mM) was added to the culture medium. The putati...
متن کاملAnalysis and chromosomal mapping of Leishmania (Leishmania) amazonensis amastigote expressed sequence tags.
The characterization of expressed sequence tags (ESTs) generated from a cDNA library of Leishmania (Leishmania) amazonensis amastigotes is described. The sequencing of 93 clones generated new L. (L.) amazonensis ESTs from which 32% are not related to any other sequences in database and 68% presented significant similarities to known genes. The chromosome localization of some L. (L.) amazonensis...
متن کاملEffect of glycosphingolipids purified from Leishmania (Leishmania) amazonensis amastigotes on human peripheral lymphocytes.
The effect of purified glycosphingolipids from Leishmania (Leishmania) amazonensis on human lymphoproliferation, on expression of human lymphocyte and monocyte markers (CD3, CD4, CD8, CD14, CD19, and CD45), and on lymphocyte protein kinase C activity was analyzed.
متن کاملLeishmania amazonensis
Resistance to and recovery from leishmania infection is dependent on cell-mediated immunity. C57BL/6 mice are resistant to Leishmania amazonensis (La) infection but susceptible to LP-BM5 murine leukemia virus (MuLV) infection. MuLVinfection leads to a state ofimmunodeficiency characterized by severe compromise ofcell-mediated immunity. When infected with La alone, C57BL/6 mice developed a smaU ...
متن کاملSphingolipid Degradation in Leishmania (Leishmania) amazonensis
BACKGROUND Human leishmaniasis is caused by more than 20 Leishmania species and has a wide range of symptoms. Our recent studies have demonstrated the essential role of sphingolipid degradation in the virulence of Leishmania (Leishmania) major, a species responsible for localized cutaneous leishmaniasis in the Old World. In this study, we investigated the function of sphingolipid degradation in...
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ژورنال
عنوان ژورنال: Brazilian Journal of Medical and Biological Research
سال: 2007
ISSN: 1414-431X,0100-879X
DOI: 10.1590/s0100-879x2006005000106